Macrophages induce differentiation of plasma cells through CXCL10/IP-10
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چکیده
منابع مشابه
Macrophages induce differentiation of plasma cells through CXCL10/IP-10
In tonsils, CD138(+) plasma cells (PCs) are surrounded by CD163(+) resident macrophages (Ms). We show here that human Ms (isolated from tonsils or generated from monocytes in vitro) drive activated B cells to differentiate into CD138(+)CD38(++) PCs through secreted CXCL10/IP-10 and VCAM-1 contact. IP-10 production by Ms is induced by B cell-derived IL-6 and depends on STAT3 phosphorylation. Fur...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2012
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20112142